INST Faculty Directory

Dr. Surajit Karmakar

Associate Professor (Scientist E)

Educational background

    1997: BSc from University of Calcutta, India Subject: Physiology (Honors), Zoology, Chemistry
    1999: MSc from University of Calcutta, India Subject: Physiology
    2003: PhD from University of Calcutta, India Subject: Physiology

Positions held

♦ Post Doctoral Fellow at The Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland, Brisbane, St Lucia, QLD 4072, Australia. 2012-2014
♦ Research Associate at Department of Biochemistry & Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.  2010-2011
♦ Postdoctoral fellow at Department of Pathology, Microbiology and Immunology and Chemical Engineering, University of South Carolina, Columbia, SC 29209, USA. 2008-2010
♦ Postdoctoral fellow at Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA. Employment Period: 2004-2007

Research Interest

Development of cancer nano-therapeutics including screening of peptide and small molecule combinatorial therapy, siRNA delivery and peptide-mediated cancer therapy by targeting mitochondrial metabolism. Understanding molecular mechanisms to overcome resistance to chemotherapy, target validation, signal transduction in membrane proteins and nanoparticles endocytotic cascade. Receptor and ion channel regulation on cell membrane organization, endosomal function and escape.

Awards

♦ New Staff Development Grant: University of Queensland, 2013
♦ Young Investigator Award, American Society for Neurochemistry, 2005
♦ Senior Research Fellow, ICMR, New Delhi, India, 2002-2004

Selected Publications

♦ Bhargava A, Pareek V,  Roy Choudhury S,  Panwar J, and Karmakar S. (2018) Superior bactericidal efficacy of fucose functionalized silver nanoparticles against Pseudomonas aeruginosa PAO1 and prevention of its colonization on urinary catheters. ACS Applied Materials and Interfaces, 10(35):29325-29337.

♦ Srivastava AK, Dev A, Choudhury SR, Karmakar S. (2018) New Insight into Curcumin Tethered Lanthanum Carbonate Nanospheres and Protein Corona Conferring Fluorescence Enhancement based Sensitive Detection of Amyloid-beta Aggregates.Sensors and Actuators B: Chemical 262, 687-695.

♦Singh PK, Srivastava AK, Dev A, Kaundal B, Choudhury SR, Karmakar S.  (2018) 1,3βGlucan anchored, paclitaxel loaded chitosan nanocarrier endows enhanced hemocompatibility with efficient anti-glioblastoma stem cells therapy. Carbohydr Polym. 180:365-375.

♦ Dev A, Srivastava A and Karmakar S. New Generation hybrid nanobiocatalysts: The catalysis redefined, In: “Handbook of Nanomaterials for Industrial Applications” Elsevier Press, 1st Edition,eBook ISBN: 9780128133521, July 2018.

♦ Srivastava A, Dev A, Karmakar S. Current trends and recent innovations in nanosensors and nanobiosensors: perspective into food and agriculture sector. Environ Chem Lett, 2017, DOI: 10.1007/s10311-017-0674-7.

♦ Dev A., Srivastava, A.K. and Karmakar, S. Nanomaterial toxicity for plants. Environ Chem Lett, 2017, 1-16. https://doi.org/10.1007/s10311-017-0667-6.

♦ Srivastava A, Dev A, Karmakar S. Nanosensors and Nanobiosensors: Current trend and innovation in perspective of Food and Agriculture Sector. In Nanoscience in Food and Agriculture. Vol 5, 2017, 41-79 (Springer International Publishing).

♦ Yadav KS, Kumar Srivastava A, Dev A, Kaundal B, Roy Choudhury S, Karmakar S. Nanomelatonin triggers superior anticancer functionality in a human malignant glioblastoma cell line. Nanotechnology, 2017, 28: 365102. doi: 10.1088/1361-6528/aa7c76.

♦ Dev A, Srivastava A and Karmakar S. Nano-toxicity and Plants. In Nanoscience in Food and Agriculture. Vol 5, 2017, 169-204 (Springer International Publishing).

♦ Agrawal, M., Yadav, S.K., Agrawal, S.K, Karmakar S. Nutraceutical phycocyanin nanoformulation for efficient drug delivery of paclitaxel in human glioblastoma U87MG cell line. J Nanopart Res, 2017,19: 272. doi.org/10.1007/s11051-017-3972-x.

♦ Dev A, Srivastava AK, Roy Choudhury S, Karmakar S. Nano-curcumin influences blue light photodynamic therapy for restraining glioblastoma stem cells growth. RSC Adv. 2016, 6, 95165-95168.

♦ Meka AK, Niu Y, Karmakar S, Hartono SB, Zhang J, Xiang C, Lin C, Zhang H, Whittaker A, Jack K, Yu M, Yu C (2016). Facile Synthesis of Large‐Pore Bicontinuous Cubic Mesoporous Silica Nanoparticles for Intracellular Gene Delivery. ChemNanoMat ChemNanoMat, 2, 220–225.

♦        Ahmad Nor Y, Niu Y, Karmakar S, Zhou L, Xu C, Zhang J, Zhang H, Yu M, Yu C(2015). Shaping Nanoparticles with Hydrophilic Compositions and Hydrophobic Properties as Nanocarriers for Antibiotic Delivery. ACS Central Science 1 (6), 328-334.

♦ Jambhrunkar S, Qu Z, Popat A, Yang J, Noonan O, Acauan L,  Nor YA, Yu C, Karmakar S. (2014) Effect of Surface Functionality of Silica Nanoparticles on Cellular Uptake and Cytotoxicity. Mol Pharm 2014 Oct 6;11(10):3642-55.

♦ Zhang J, Karmakar S, Yu M, Mitter N, Zou J, Yu C. (2014) Synthesis of Silica Vesicles with Controlled Entrance Size for High Loading, Sustained Release, and Cellular Delivery of Therapeutical Proteins. Small 2014 Dec 29;10(24):5068-76. Equal first authorship.

♦ Jambhrunkar S, Qu Z, Popat A, Karmakar S,  Xu C, Yu C. (2014) Modulating in vitro release and solubility of griseofulvin using functionalized mesoporous silica nanoparticles. J Colloid Interface Sci., 434:218-25.

♦ Yang Y, Karmakar S, Zhang J, Yu M, Mitter N, Yu C. (2014) Synthesis of SBA-15 rods with small sizes for enhanced cellular uptake. Journal of Materials Chemistry B, 2 30: 4929-4934. Equal first authorship.

Conferences

♦ Davis KA, Karmakar S, Choudhury SR, Banik NL and Ray SK (2010) Synergistic efficacy of HA14-1 and apigenin in inhibiting angiogenic factors and increasing apoptosis in neuroblastoma cells. Frontiers in Neuroscience Conference. March 05 - 07, 2010, Atlanta, USA.

♦ Karmakar S, Banik NL, Ray SK (2009)Combination of ATRA and IFN-γ for increasing apoptosis in glioblastoma U87MG xenografts in nude mice. Annual ASN Meeting, Charleston, SC - March 7-11 2009, USA.

♦ Roy Choudhury S, Karmakar S, Banik NL, Ray SK (2009) Combination of valproic acid and taxol or nanotaxol induced differentiation and apoptosis in glioblastoma LN18 and T98G cells. Annual ASN Meeting, Charleston, SC - March 7-11 2009, USA.

♦ Mohan N, Karmakar S, Roy Choudhury S, Banik NL , Ray SK (2009) Small Molecule Inhibitor of Bcl-2 Enhances Efficacy of Genistein for Apoptosis in Neuroblastoma SH-SY5Y and SK-N-BE2 Cell lines. Annual ASN Meeting, Charleston, SC - March 7-11, 2009, USA.

♦ Davis K, Karmakar S, Roy Choudhury S, Deeconda A, Banik NL, Ray SK (2009)  Combination of Bcl-2 inhibitor and apigenin activated extrinsic and intrinsic pathways of apoptosis in neuroblastoma SK-N-DZ cells. Annual ASN Meeting, Charleston, SC - March 7-11, 2009, USA.

♦ Roy Choudhury S, Karmakar S, Banik NL, Ray SK (2009) Combination of sorafenib and genistein inhibits angiogenesis and triggers multiple molecular mechanisms for apoptosis in human malignant neuroblastoma SK-N-DZ and SH-SY5Y cell lines. AACR Annual Meeting April 18-22, 2009, Denver, CO, USA.

♦ Karmakar S, Roy Choudhury S, Tomlinson S, Banik NL, Ray SK (2009)Combination of N-(4-hydroxyphenyl) retinamide and genistein increases apoptosis in Ewing’s sarcoma SK-N-MC cells in culture and xenografts in athymic nude mice. AACR Annual Meeting April 18-22, 2009, Denver, CO, USA.

♦ Karmakar S, Banik NL, Ray SK (2008)Development of guide-cannula intracranial allograft model of glioblastoma in Sprague-Dawley rats.  Annual ASN Meeting, San Antonio, Texas, March 1 - 5, 2008, USA.

♦ Karmakar S, Walle T, Banik NL, Ray SK  (2008)  Treatment with combination of all-trans retinoic acid and interferon-gamma regressed human glioblastoma T98G xenografts in nude mice. Annual meeting of the American Association for Cancer Research (AACR), April 14-18, San Diego, CA, USA.

♦ Karmakar S, Patel SJ, Banik NL, Ray SK (2007)Photodynamic therapy activated proteolytic pathways for apoptosis in human glioblastoma U87MG cells. Frontier Research Day, MUSC, SC, USA.

♦ Karmakar S, Patel SJ, Walle T, Banik NL, Ray SK (2007) Combination of N-(4-hydroxyphenyl) retinamide and genistein induced differentiation and multiple molecular mechanisms for apoptosis in human malignant neuroblastoma SK-N-BE(2) xenografts in nude mice.  Annual meeting of the American Association for Cancer Research (AACR), April 14-18, Los Angeles, CA, USA.

♦ Karmakar S, Banik NL, Patel SJ, and Ray SK (2006) Curcumin activated calpain and caspases in human malignant glioblastoma U87MG cells for apoptosis. AACR Annual Meeting, April 1-5, 2006 at Washington, DC.

♦ Karmakar S, Banik NL, Patel SJ, and Ray SK (2006)  Molecular mechanism of inositol hexaphosphate mediated apoptosis in human malignant glioblastoma T98G cells.  Program No. 389.9. 2006 Abstract Viewer/Itinerary Planner. Atlanta, GA: Society for Neuroscience, USA.

♦ Mao T, Karmakar S, Banik NL, Ray SK (2006) Inositol hexaphosphate induced apoptosis in human malignant glioblastoma U87MG cells. MUSC Student Research Day. Charleston, SC, USA.

♦ Karmakar S, Das A, Banik NL, Patel SJ, Ray SK (2005)   Induction of calpain and intrinsic caspase  pathways for apoptosis in human malignant neuroblastoma cell line SHSY-5Y following exposure to dially sulphide (DAS) and diallyl disulphide (DADS). AACR Annual Meeting April 16 - 20, 2005, Anaheim, California.

♦ Karmakar S, Weinberg MS, Das A, Banik NL, Patel SJ, Ray SK (2005) Activation of multiple molecular mechanisms for of apoptosis in human malignant glioblastoma cell lines T98G and U87MG following exposure to L-sulphoraphane. AACR Annual Meeting April 16 - 20, 2005, Anaheim, California.

♦ Karmakar S, Das A, Tomlinson S, Banik NL, Patel SJ, Ray SK (2005) Treatment with combination of all trans-retinoic acid and taxol induced differentiation and apoptosis in human malignant glioblastoma U87MG cells xenografted in athymic nude mice. AACR Annual Meeting April 16 - 20, 2005, Anaheim, California.

♦ Karmakar S, Das A, Banik NL, Patel SJ, Ray SK (2005)Combination of retinoid and flavonoid controlled the growth of human malignant neuroblastoma SHSY5Y cells in culture as well as xenografted athymic nude mice.  AACR Annual Meeting April 16 - 20, 2005, Anaheim, California.

♦ Das A, Karmakar S, Patel SJ, Banik NL, and  Ray SK (2005) All- trans retinoic acid and 13-cis retinoic acid differentiated rat C6 glioblastoma cells and decreased telomerase activity leading to increased sensitivity to IFN- γ and taxol for apoptosis. AACR Annual Meeting April 16 - 20, 2005, Anaheim, California.

♦ Das A, Karmakar S, Patel SJ, Banik NL, and Ray SK (2005)Activation of proteolytic activities of calpain and caspase-3 in apoptosis of human malignant glioblastoma cell lines T98G and U87MG exposed to diallyl sulphide (DAS) and dially disulphide (DADS). AACR Annual Meeting April 16 - 20, 2005, Anaheim, California.

♦ Das A, Karmakar S, Styart RK, Patel SJ, Banik NL, and Ray SK (2005)Plant derived flavonoids induced proteolytic activities of calpain and caspase-3 for apoptosis in human malignant glioblastoma U87MG cells. AACR Annual Meeting April 16 - 20, 2005, Anaheim, California.

♦ Das A, Karmakar S, Patel SJ, Priest DG, Banik NL, and Ray SK(2005) Differentiation of human glioblastoma U87MG cells with all-trans retinoic acid (ATRA) or 13-cis retinoic acid (13-CRA) down regulated telomerase activity and enhanced sensitivity to interferon –gamma (IFN-γ) or taxol (TXL) for apoptosis. AACR Annual Meeting April 16 - 20, 2005, Anaheim, California.

♦ Das A, Karmakar S, Patel SJ, Banik NL, and Ray SK(2005) Exploration of the potential of N-(4-hydroxyphenyl) retinamide (4-HPR) for induction of both differentiation and apoptosis in two human malignant glioblastoma cell lines T98G and U87MG. AACR Annual Meeting April 16 - 20, 2005, Anaheim, California.

♦ Ray SK, Das A, Karmakar S, Banik NL, Patel SJ (2005) Activation of proteolytic pathways by polyphenolic phytochemicals for apoptosis in human glioblastoma T98G cells. European Winter Oncology Conference, Sunday 16 - Friday 21 May 2005 at  Edinburgh, United Kingdom.

♦ Ray SK, Karmakar S, Das A, Banik NL, Patel SJ (2005) Human glioblastoma T98G cells xenografted in athymic nude mice overwhelmingly committed after treatment with all-trans retinoic acid and taxol. European Winter Oncology Conference, Sunday 16 - Friday 21 May 2005 at  Edinburgh, United Kingdom.

♦ Karmakar S, Saha A, Das A, Banik NL, Ray SK (2005)  Curcumin activated multiple molecular mechanisms for   apoptosis in human glioblastoma T98 cells. Annual Meeting of American Society for Neurochemistry at Madison, Wisconsin, June 25-29, 2005.

♦ Das A, Karmakar S, Saha A, Banik NL, Ray SK (2005) Dexamethasone decreases while acetazolomide increases   temozolomide induced apoptosis in human glioblastoma cells. Annual Meeting of American Society for Neurochemistry at Madison, Wisconsin, June 25-29, 2005.

♦ Karmakar S, Banik NL, Patel SJ, and Ray SK (2005)  A combination therapy for enhancement of apoptosis in human malignant glioblastoma T98G and U87MG cells xenografted in nude mice. International Symposium on Translational Research: Apoptosis and Cancer.

♦ Fry P, Karmakar S, Matzelle D, Banik NL, Ray SK (2005) A potential role for calpain in pathogenesis of kainic acid-induced epileptic seizures in sprague-dawley rats. MUSC Student Research Day., SC, USA.

♦ Karmakar S, Yallapragada AV, Das A, Banik NL, Patel SJ, Ray SK  (2004) Activation of proteolytic mechanisms in apoptosis of human malignant neuroblastoma SH-SY5Y cells exposed to diallyl disulphide (DADS). MUSC Student Research Day.

♦ Das A, Banik NL, Karmakar S, Patel SJ, Ray SK (2004) All-trans retinoic acid decreased telomerase activity and increased IFN-γ and taxol induced apoptosis in human glioblastoma T98G cells. SFN Annual Meeting.

♦ Karmakar S, Gomes A (2003) Occurrence of an antineoplastic compound (CSS-ANF) from the skin of the snake head fish Channa striatus, Linn. XXXVI Annual Conference of the Indian Pharmacological Society.

Patent

A process for the isolation of a novel antineoplastic compound useful for pharmacological purposes. Gomes A, Karmakar S, Gomes A, Das T, Ghosh A, Biswas AK, Dasgupta SC (Patent filed through the Intellectual Property Cell, ICMR, New Delhi; Ref. No: 832/Del/2003, June 23, 2003).

Office Address:

Institute of Nano Science & Technology
Habitat Centre, Phase X, Sector - 64, Mohali, Punjab-160062, India

Contact info:

Tel: 0172 - 2210075 (Ext. 1116
Email Id : surajit(at)inst(dot)ac(dot)in