INST Faculty Directory
Dr Rehan Khan
Scientist B
Educational Qualification:

Ph.D. (Toxicology), 2009 - 2013, Department of Toxicology, Jamia Hamdard (Hamdard University), New Delhi, India.
M.Sc. (Toxicology), 2004 - 2006, Department of Toxicology, Department of Toxicology, Jamia Hamdard (Hamdard University), New Delhi, India.
B.Sc.  Hons. (Botany), 2001 - 2004, Department of Botany, Aligarh Muslim University, Aligarh, India.

Positions held :

Oct. 2013-June 2014, Post-doctoral Fellow at Manitoba Institute of Cell Biology, Cancercare Manitoba, University of Manitoba, Winnipeg, MB, CANADA.
2011 - 2013, Senior Research Fellowship (SRF) by Indian Council of Medical Research (ICMR), New Delhi, India.
2009 – 2011, Research Fellowship for Science and Meritorious Student (RFSMS) by University Grants Commission (UGC), New Delhi, India.

Research interests :

Synthetic Lethality and Cancer
Cancer Chemoprevention
Targeted Cancer Therapy by small molecule inhibitors/nano-formulations

Awards :

Travel Grant awarded by Department of Science and Technology, Ministry of Higher Education, New Delhi, India, for attending international conference “The Tumor Microenvironment” held in Dublin, Ireland in September 2012.

Award from Jamia Hamdard (Hamdard University) for publishing research work in high impact (more than 3.0) journals “PLoS One”, “British Journal of Nutrition” and “Toxicology and Applied Pharmacology”.

Professional Membership :

Member of Royal Microscopical Society

Publications and Patent :

1. Khan R, Sultana S. Farnesol attenuates 1,2-dimethylhydrazine induced oxidative stress, inflammation and apoptotic responses in the colon of Wistar rats. Chemico-Biological Interactions 2011 Jul 15;192(3):193-200. [PMID: 21453689].

2. Khan R, Khan AQ, Qamar W, Lateef A, Tahir M, Rehman MU Ali F, Sultana S. Chrysin protects against cisplatin-induced colon toxicity via amelioration of oxidative stress and apoptosis: probable role of p38MAPK and p53.Toxicology and Applied Pharmacology, 2012 Feb 1; 258(3):315-29. [PMID: 22155348].

3. Khan R, Abdul Quaiyoom Khan, Wajhul Qamar, Abdul Lateef, Farrah Ali, Muneeb U. Rehman, Mir Tahir, Swati Sharma and Sarwat Sultana. Chrysin abrogates cisplatin-induced oxidative stress, p53 expression, goblet cell disintegration and apoptotic responses in the jejunum of Wistar rats. British Journal of Nutrition, 2012 Nov 14;108(9):1574-85. PMID: 22309980].

4. Khan AQ, Khan R, Rehman MU, Lateef A, Tahir M, Ali F, Sultana S. Soy isoflavones (daidzein&genistein) inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cutaneous inflammation via modulation of COX-2 and NF-κB in Swiss albino mice. Toxicology. 2012 Dec 16;302(2-3):266-74.[PMID: 22981962].

5. Qamar W, Khan AQ, Khan R, Rehman MU, Lateef A, Tahir M, Ali F, Sultana S. Benzo(a)pyrene-Induced Pulmonary Inflammation, Edema, Surfactant Dysfunction, and Injuries in rats: Alleviation by Farnesol. Experimental Lung Research. 2012 Feb;38(1):19-27.  [PMID: 22168545].

6. Hamiza OO, Rehman MU, Tahir M, Khan R, Khan AQ, Lateef A, Ali F, Sultana S. Amelioration of 1,2 Dimethylhydrazine (DMH) induced colon oxidative stress, inflammation and tumor promotion response by tannic acid in Wistar rats. Asian Pac J Cancer Prev. 2012;13(9):4393-402.

7. Qamar W, Khan R, Khan AQ, Rehman MU, Lateef A, Tahir M, Ali F, Sultana S. Alleviation of lung injury by glycyrrhizic acid in benzo(a)pyrene exposed rats: Probable role of soluble epoxide hydrolase and thioredoxin reductase. Toxicology 2012 Jan 27;291(1-3):25-31. [PMID: 22051199].

8. Khan AQ, Khan R, Qamar W, Lateef A, Ali F, Tahir M, Muneeb-U-Rehman, Sultana S. Caffeic acid attenuates 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced NF-κB and COX-2 expression in mouse skin: Abrogation of oxidative stress, inflammatory responses and proinflammatory cytokine production. Food and Chemical Toxicology. 2012 Feb;50(2):175-83. [PMID: 22036979].

9. Sultana S, Verma K, Khan R. Nephroprotective efficacy of chrysin against cisplatin induced toxicity via attenuation of oxidative stress. Journal of Pharmacy and Pharmacology, 2012 Jun;64(6):872-81.[PMID: 22571266].

10. Rehman MU, Tahir M, Ali F, Qamar W, Lateef A, Khan R, Quaiyoom A,  Oday-O-Hamiza, Sultana S. Cyclophosphamide-induced nephrotoxicity, genotoxicity, and damage in kidney  genomic DNA of Swiss albino mice: the protective effect of  Ellagic acid. Molecular and Cellular Biochemistry. 2012 Jun; 365(1-2):119-27. [PMID: 22286819].

11. Rehman MU, Tahir M, Ali F, Qamar W, Khan R, Khan AQ, Lateef A, Hamiza OO, Sultana S. Chemopreventive effect of Quercus infectoria against chemically induced renal toxicity and carcinogenesis. International Journal of Drug Development & Research, 2012, 4 (2): 336-351.

12. Rehman MU, Tahir M, Khan AQ, Khan R, Lateef A, Hamiza OO, Kazim S, Ali F, Sultana S. Methanolic extract of Bacop amonnieri protects against KBrO3-induced renal damage in Wistar rats by restoring antioxidant enzyme activities and suppressing inflammation and apoptosis. Journal of Pharmacy Research, 2012,5(11),5231-5238.

13. Khan R, Khan AQ, Lateef A, Rehman MU, Tahir M,  Ali F, Hamiza OO, Sultana S. Glycyrrhizic acid suppresses the development of precancerous lesions via regulating thehyperproliferation, inflammation, angiogenesis and apoptosis in the colon of Wistar rats. PLoS One. 2013;8(2):e56020. [PMID: 23457494].

14. Ali F, Khan R, Khan AQ, Lateef A, Tahir M, Sultana S. Assessment of augmented immune surveillance and tumor cell death by cytoplasmic stabilization of p53 as a chemopreventive strategy of three promising medicinal herbs in murine two stage skin carcinogenesis. Integrative Cancer Therapies, 2013 Dec 19;13(4):351-367. [PMID: 24363284].

15. Tahir M, Rehman MU, Lateef A, Khan AQ, Khan R, Qamar W, Hamiza OO, Ali F, Hasan SK, Sultana S. Diosmin abrogates chemically induced hepatocarcinogenesis via alleviation of oxidative stress, hyperproliferative and inflammatory markers in murine model. Toxicology Letters, 2013; 220(3):205-18. [PMID: 23665045].

16. Khan AQ, Khan R, Qamar W, Lateef A, Rehman MU, Tahir M, Ali F, Hamiza OO, Hasan SK, Sultana S. Geraniol attenuates 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced oxidative stress and inflammation in mouse skin: possible role of p38 MAP Kinase and NF-κB. Experimental and Molecular Pathology 2013 Feb 8;94(3):419-429. [PMID: 23399806].

17. Rehman MU, Tahir M, Khan AQ, Khan R, Lateef A, Oday-O-Hamiza, Qamar W, Ali F, Sultana S. Chrysin suppresses renal carcinogenesis via amelioration of hyperproliferation, oxidative stress and inflammation: plausible role of NF-κB. Toxicology Letters 2013 Feb 4;216(2-3):146-58. [PMID: 23194824].

18. Rehman MU, Tahir M, Khan AQ, Khan R, Lateef A, Oday-O-Hamiza, Ali F, Sultana S. Diosmin protects against TCE (trichloroethylene) induced renal injury in Wistar rats: Plausible role of p53, Bax and caspases. British Journal of Nutrition, 2013 Feb 12:1-12. [PMID: 23402272].

19. Lateef A, Khan AQ, Tahir M, Khan R, Rehman MU, Ali F,Hamiza OO, Sultana S.Androgen deprivation by flutamide modulates uPAR, MMP-9 expressions, lipid profile and oxidative stress: amelioration by daidzein. Molecular and Cellular Biochemistry, 2013 Feb;374(1-2):49-59. [PMID: 23135684].

20. Tahir M, Rehman MU, Lateef A, Khan R, Khan AQ, Ali F, Oday-O-Hamiza, Sultana S. Diosmin protects against ethanol-induced hepatic injury via alleviation of inflammation and regulation of TNF-α and NF-κB activation. Alcohol, 2013 Mar;47(2):131-9. [PMID: 23419394].

21. Lateef A, Rehman MU, Tahir M, Khan R, Khan AQ, Qamar W, Sultana S. Farnesol protects against intratracheally instilled cigarette smoke extract-induced histological  alterations and oxidative stress in prostate of Wistar rats. Toxicology International, 2013 Jan;20(1):35-42. [PMID: 23833436].

22. Rehman MU, Tahir M, Quaiyoom A, Khan R, Lateef A, Oday-O-Hamiza, Hassan SK, Ali N, Qamar W, Sultana S. Alleviation of hepatic injury by chrysin in cisplatin administered rats: Probable role of inflammatory markers. Pharmacol Reports; 2014; 66(6):1050-9. [PMID: 25443734].

23. Khan AQ, Khan R, Tahir M, Lateef A, Rehman MU, Ali F, Hamiza OO, Hasan SK, Sultana S. Silibinin inhibits tumor promotional triggers and tumorigenesis against chemically induced two-stage skin carcinogenesis in Swiss albino mice: Possible role of oxidative stress and inflammation. Nutrition and Cancer, 2014;66(2):249-58. [PMID: 24364787].

24. Rehman MU, Tahir M, Khan AQ, Khan R, Oday-O-Hamiza, Lateef A, Hassan SK, Rashid S, Ali N, Zeeshan M, Sultana S.. D-limonene suppresses Doxorubicin induced oxidative stress and inflammation via repression of COX-2, iNOS, and NFκB in kidneys of Wistar rats. Experimental Biology and Medicine (Maywood) 2014 Apr;239(4):465-76. [PMID: 24586096].

25. Hamiza OO, Rehman MU, Khan R, Tahir M, Khan AQ, Lateef A, Sultana S. Chemopreventive effects of Aloin against DMH-induced preneoplastic lesions in the colonof Wistar rats. Human and Experimental Toxicology, 2014 Feb;33(2):148-63. [PMID: 23928829].

26. Hamiza OO,Rehman MU, Tahir M, Khan R, Lateef A, Khan AQ, Qamar W, Sultana S. Methanolic extract of Terminalia chebula protects against DMH-induced colon damage in Wistar Rats by restoring antioxidant enzyme activities and suppressing inflammation. International Journal of Drug Development & Research, 2014, Vol. 6, Issue 1, ISSN 0975-9344.

27. Majed F, Rashid S, Khan AQ, Nafees S, Ali N, Ali R, Khan R, Hasan SK, Mehdi SJ, Sultana S. Tannic acid mitigates the DMBA/croton oil-induced skin cancer progression in mice. Molecular and Cellular Biochemistry. 2015 Jan;399(1-2):217-28. [PMID: 25399297].

28. Hasan SK, Khan R, Ali N, Khan AQ, Rehman MU, Tahir M, Lateef A, Nafees S, Mehdi SJ, Rashid S, Shahid A, Sultana S. 18-β Glycyrrhetinic acid alleviates 2-Acetylaminofluorene induced hepatotoxicity in wistar rats: Role in hyperproliferation, inflammation and oxidative stress. Human and Experimental Toxicology, 2015 Jun;34(6):628-41.

29. Gupta A, Ahmad A, Dar AI, Bhatt A, Khan R*. Selective Targeting of Cancer Cells using Personalized Nanomedicine. Toxicolology and Forensic Medicine Open Journal, 2016; 1(1), e12-e13.  doi: 10.17140/ TFMOJ-1-e005. (*Corresponding Author).

30. Ali F, Khan AQ, Khan R,Sultana S. Trichloroethylene mediated cytotoxicity in Human Epidermal Keratinocytes is mediated by the rapid accumulation of intracellular calcium: Interception by Naringenin. Human and Experimental Toxicology. 2016 Feb;35(2):147-61. [PMID: 25855085].[Epub ahead of print].

31. Gupta A, Ahmad A, Dar AI, Khan R*. Synthetic lethality: From Research to Personalized Cancer Nanomedicine. Current Cancer Drug Targets, 2017. (Accepted). (*Corresponding Author).

32. Gupta A, Ahmad A, Singh S, Kaur S, Neethu K M, Ansari MM, Jayamurugan G,* and Khan R*. Nanocarrier Composed of Magnetite Core Coated with Three Polymeric Shells Mediates LCS‑1 Delivery for Synthetic Lethal Therapy of BLM-Defective Colorectal Cancer Cells. Biomacromolecules, 2018. 19(3):803-815. (*Corresponding Author).

33. Khan R, Rehman MU, Khan AQ, Tahir M, Sultana S. Glycyrrhizic acid suppresses 1,2-dimethylhydrazine-induced colon tumorigenesis in Wistar rats: Alleviation of inflammatory, proliferation, angiogenic, and apoptotic markers. Environmental Toxicology. 2018. (Accepted). In Press.

34. Rehman MU, Wali AF, Ahmad A, Shakeel S, Rasool S, Ali R, Rashid SM, Madkhali H, Ganaie MA, Khan R*. Neuroprotective Strategies for Neurological Disorders by Natural Products: An update. Current Neurophaamacology 2018, (Accepted). In Press. (*Corresponding Author).

Conferences Presented :

1. EACR-IACR special conference “The Tumour Microenvironment” Dublin, Ireland in September 2012.
2. Indo-UK Seminar on “Biomarkers of Ecotoxicity, cancer, Monitoring and Prevention” held at Jamia Hamdard in 2004.
3. XXIX Annual Conference of Society of Toxicology (STOX), India and International Symposium on “Current Trends in Toxicology and Pre-clinical Toxicology” held at Food and Drug Toxicology Research Centre, National Institute of Nutrition, Indian Council of Medical Research, Hyderabad, in 2009.
4. 30th Annual Conference of Society of Toxicology (India) and Symposium on Strategies for Safety Study Requirements for Herbal Formulations, held at Jamia Hamdard, New Delhi in 2010.
5. Manuscript Writing Workshop, held at Jamia Hamdard, New delhi in 2011.
6. Hands-on Training on Flow Cytometry by BD Biosciences, at Jamia Hamdard (BD-JH FACS Academy), New Delhi in February 2013.

CONTACT INFORMATION :

Tel: 0172 - 2210075
Email Id : rehankhan(at)inst(dot)ac(dot)in

Office Address :

Institute of Nano Science & Technology
Habitat Centre, Sector - 64, Phase X, Mohali