INST Faculty Directory

Dr. Sangita Roy

Scientist C
Educational Qualification:

PhD:  2009, Indian Association for the Cultivation of Science, Kolkata, India.

MSc: 2002, Department of Chemistry, University of Calcutta, India.

BSc: 2000, Department of Chemistry, University of Calcutta, India.

Positions Held/Research Experience:

♦ Visiting Scientist, Institute of Nano Science and Technology, Mohali, India (July 2013-January 2014).

♦ Post Doctoral Research Fellow, Department of Pure & Applied Chemistry, University of Strathclyde, Glasgow, UK (2009-2013).

♦ Consultant, BioGelx, Glasgow, UK (2013)

♦ PhD Research Fellow, Department of Biological Chemistry, Indian Association for the Cultivation of Science, Kolkata, India (2004-2009).

♦ Project Associate, ChemBiotek Research International Pvt. Ltd., Kolkata, India (2002-2003).

Research Areas :

♦  Our research focuses on design and development of new biofunctional nanomaterials based on sugar-peptide conjugates. Molecular self-assembly approach will be followed for bottom-up nanofabrication of these soft namomaterials to generate a variety of nanostructures. These supramolecular nanomaterial scaffolds will be explored towards solving the problems of biology (e.g. drug delivery, cancer therapy, regenerative medicine) and energy resources.

Recent Publication ( H-index=15):

♦ Y. M. Abul-Haija, S. Roy, P. W. J. M. Frederix, N. Javid, V. Jayawarna and R.V. Ulijn, Biocatalytically Triggered Co-Assembly of Two-Component Core/Shell Nanofibers, Small 2014, 10, 973-979.

♦ S. Debnath, S. Roy and R.V. Ulijn, Peptide Nanofibers with Dynamic Instability through Non-Equilibrium Biocatalytic Assembly, J. Am. Chem. Soc. 2013, 135, 16789-16792.

♦ N. Javid, S. Roy, M. Zelzer, Z. Yang, J. Sefcik and R.V. Ulijn, Cooperative Self-Assembly of Peptide Gelators and Proteins, Biomacromolecules  2013, 14, 4368–4376.

♦ G. Scott, S. Roy, Y. M. Abul-Haija, S. Fleming, S. Bai and R.V. Ulijn, Pickering Stabilized Peptide Gel Particles as Tunable Microenvironments for Biocatalysis, Langmuir 2013, 29, 14321-14327.

S. Roy, N. Javid, J. Sefcik, P. J. Halling, and R. V. Ulijn, Salt-Induced Control of Supramolecular Order in BiocatalyticHydrogelation, Langmuir 2012, 28, 16664–16670. (As Corresponding author).

S. Roy, N. Javid, P. W. J. M. Frederix, D. A. Lamprou, A. J. Urquhart, N. T. Hunt, P. J. Halling, and R. V. Ulijn, Dramatic Specific Ion Effect in Supramolecular Hydrogels, Chem. Eur. J. 2012, 18, 11723-11731 (As Corresponding author).

♦ L. S. Birchall, S. Roy, V. Jayawarna, M. Hughes, E. Irvine, G. T. Okorogheye, N. Saudi, E. De Santis, T. Tuttle, A. A. Edwards and R. V. Ulijn, Exploiting CH-π Interactions in Supramolecular Hydrogels of Aromatic Carbohydrate Amphiphiles, Chem. Sci. 2011, 2, 1349-1355 (Selected as cover picture of the issue).

♦ N. Javid, K. Vogtt, S. Roy, A. R. Hirst, A. Hoell, I. W. Hamley, R. V. Ulijn and J. Sefcik, Supramolecular Structures of Enzyme Clusters, J. Phys. Chem. Lett. 2011, 2, 1395-1399.

♦ A. R. Hirst†, S. Roy†, M. Arora, A. K. Das, N. Hodson, P. Murray, N. Javid, J. Sefcik, J. Boekhoven, J.H. van Esch, S. Santabarbara, N. T. Hunt and R. V. Ulijn, Biocatalytic Induction of Supramolecular Order, Nature Chemistry, 2010, 2, 1089-1094 (†Authors contributed equally).

♦ D. Das, S. Roy, S. Debnath, and P. K. Das, Surfactant-Stabilized Small Hydrogel Particles in Oil: Hosts for Remarkable Activation of Enzymes in Organic Solvents. Chem. Eur. J. 2010, 16, 4911-4922.

S. Roy, and P. K. Das, Antibacterial Hydrogels of Amino Acid-Based Cationic Amphiphiles.  Biotech. Bioeng. 2008, 100, 756-764.

S. Roy, A. Dasgupta, and P. K. Das. Alkyl Chain Length Dependent Hydrogelation of L-Tryptophan Based Amphiphile. Langmuir 2007, 23, 11769-11776.

♦ R. N. Mitra, D. Das, S. Roy, and P. K. Das, Structure and Properties of Low Molecular Weight Amphiphilic Peptide Hydrogelators. J. Phys. Chem. B 2007, 111, 14107-14113.

♦ A. Shome, S. Roy, and P. K. Das. Nonionic Surfactants: A Key to Enhance the Enzyme Activity at Cationic Reverse Micellar Interface. Langmuir 2007, 23, 4130-4136.

S. Roy, A. Dasgupta, and P. K. Das, Tailoring of Horseradish Peroxidase Activity in Cationic Water-in-Oil Microemulsions. Langmuir 2006, 22, 4567-4573.

♦ K. Mohanta, A. J. Pal, S. Roy, and P. K. Das, A Control Over Accessibility of Immobilized Enzymes through Porous Coating Layer. J. Colloid Interface Sci. 2006, 304, 329-334.

♦ D. Das, A. Dasgupta, S. Roy, R. N. Mitra, S. Debnath, and P. K. Das, Water Gelation of an Amino Acid Based Hydrogelator. Chem. Eur. J. 2006, 12, 5068-5074 (Selected as cover picture of the issue).

♦ A. Dasgupta, R. N. Mitra, S. Roy, and P. K. Das, Asymmetric Resolution in Ester Reduction by NaBH4 at the Interface of Aqueous Aggregates of Amino Acid, Peptide, and Chiral Counter-ion based Cationic Surfactants. Chem. Asian. J. 2006, 1, 780-788.

♦ D. Mitra, I. Chakraborty, S. C. Bhattacharya, S. P. Moulik, S. Roy, D. Das, and P. K. Das,  Physicochemical Studies on Cetylammonium Bromide and its Modified (mono-, di- and trihydroxyethylated) Head Group Analogues. Their Micellization Characteristics in Wwater and Thermodynamic and Structural Aspects of Water-in-Oil Microemulsion Formed with Them along with n-Hexanol and Isooctane. J. Phys. Chem. B 2006, 110, 11314-11326.

S. Roy, D. Das, A. Dasgupta, R. N. Mitra, and P. K. Das, Amino Acid Based Cationic Surfactants in Aqueous Solutions: Physicochemical Study and Application of Supramolecular Chirality in Ketone Reduction. Langmuir 2005, 21, 10398-10404.

♦ D. Das, S. Roy, R. N. Mitra, A. Dasgupta and P. K. Das,  Head Group Size or Hydrophilicity of Surfactant: the Major Regulator of Lipase Activity in Cationic w/o Microemulsions. Chem. Eur. J. 2005, 11, 4881-4889 (Selected as cover picture of the issue and frontispiece).

♦ R. N. Mitra, A. Dasgupta, D. Das, S. Roy, S. Debnath, and P. K. Das, Geometric Constraints at the Surfactant Head Group: Effect on Lipase Activity in Cationic Reverse Micelles. Langmuir 2005, 21, 12115-12123.

♦ D. Das, S. Roy, and P. K. Das, Efficient and Simple NaBH4 Reduction of Esters at Cationic Micellar Surface. Org. Lett. 2004, 6, 4133-4136.

♦ A. A. Edwards, L. S. Birchall, V. Jayawarna, S. Roy, M. Hughes, T. Tuttle, N. Saudi, G. Okorgheye, R. V. Ulijn, Fmoc Hydrogels from Aromatic Carbohydrate Amphiphiles, J. Pharm. Pharmacol.2010, 62, 1331-1332 (The UK-PharmSci Conference, The Science of Medicine, 1st –3rd September, 2010).

♦ N. Kayal, S. Roy, R. N. Mitra, P. K. Das, Antimicrobial Activity of Amino Acids and Dipeptide-based Amphiphiles, J. Biotech. 2008, 136, S28–S29 (Biotechnology for the Sustainability of Human Society, 13th International Biotechnology Symposium and Exhibition IBS 2008, 12th-17th October, China).

Books/Chapters in books:

S. Roy and R.V. Ulijn, Exploiting Biocatalysis in the Synthesis of Supramolecular Polymers, Enzymatic Polymerisations, Advances in Polymer Science, 2010, 237, 127-143.

Conferences Proceedings & Posters:

 Invited Talks:

S. Roy, 8th Chandigarh Science Congress (Chascon-2014), Panjab University, 26th-28th February, 2014.

S. Roy, International Conference on Interdisciplinary areas with Chemical Sciences (ICIACS 2013), Panjab University, 30th October -1st November, 2013.

S. Roy, R. V. Ulijn, Highly Tunable Gels via Non-equilibrium Biocatalytic Self-assembly, UK-India Symposium on Molecular Materials Chemistry, University of Strathclyde, UK, 13th September, 2012.

S. Roy, R. V. Ulijn, Peptide Hydrogels via Non-equilibrium Biocatalytic Self-assembly, RAMS Meeting, University of Strathclyde, UK, 5th – 7th September, 2012.

S. Roy, V. Jayawarna, R. V. Ulijn, Self-assembled Peptide Nanostructures: A Microscopic Insight, AFM Users Meeting, University of Strathclyde, UK, 22nd June, 2012.

S. Roy, R. V. Ulijn, Biocatalytic Self-Assembly of Supramolecular Polymers, 10th International Conference in Materials Chemistry (MC10), University of Manchester, UK, 4th – 7th July, 2011.

Poster Presentations:

S. Roy, R. V. Ulijn, Non-equilibrium Biocatalytic Self-assembly, UK-India Symposium on Molecular Materials Chemistry, The Chemistry Centre, London, UK, 10th – 11th September, 2012.

S. Roy, R. V. Ulijn, Highly tunable gels via biocatalytic non-equilibrium self-assembly, Bionanotechnology III: from biomolecular assembly to applications, Robinson College, Cambridge, UK, 4th – 6th January, 2012.

S. Roy, V. Jayawarna, R. V. Ulijn, Design and Synthesis of Enzyme-Responsive Hydrogelators for Biomedical Application, Polymeric Biomaterials Conference, University of Reading, UK, 15th -16th April, 2010.

S. Roy, V. Jayawarna, R. V. Ulijn, Design and Synthesis of Small Molecule Hydrogelators for Directing Cell Behaviour, Polymeric and self-assembling hydrogels. Macrogroup UK, University of Manchester, UK, 22nd – 23rd September, 2009.

S. Roy, P. K. Das, L-Tryptophan based amphiphilic hydrogelators:potent for biomedicinal application, 10th CRSI-RSC (2nd) National Symposium in Chemistry, Indian Institute of Science, Bangalore, India, 31st January-3rd February, 2008- Poster.

S. Roy, P. K. Das, Amino Acid Based Amphiphilic Hydrogelators: Potent for Antibacterial Activity and Controlled Release, Indo-German bilateral Seminar, Antimicrobial Drug Resistance and the Development of New Antibiotics, Indian National Science Academy, 22nd -25th November, 2007.

♦ D Das, S. Roy, A. Dasgupta, P. K. Das, Efficient and Stereoselective Ester Reduction by NaBH4 in Aqueous Self-Aggregates of Cationic Surfactants, National Symposium on Organic Chemistry-III, Department of Chemistry, Jadavpur University, Kolkata, 22nd- 23rd February, 2006.

♦ D Das, S. Roy, A. Dasgupta, P. K. Das, Efficient Ester Reduction Simply by NaBH4 in Aqueous Self-Aggregate of Cationic Surfactants, 8th CRSI National Symposium in Chemistry, Institute of Technology, Mumbai, India, 3rd – 5th February, 2006.

S. Roy, D. Das, A. Dasgupta, R. N. Mitra, P. K. Das, Supramolecular Chirality in Aqueous Solution of Amino Acid Based Cationic Surfactants: Application to Ketone Reduction, Joint International Conference on Building Bridges, Forging Bonds for 21st Century Organic Chemistry and Chemical Biology (ACS-CSIR OCCB), National Chemical Laboratory, Pune, 6th -9th January, 2006.

♦ D. Das, S. Roy, R. N. Mitra, A. Dasgupta, P. K. Das, Predominant Role of Headgroup Size over Hydrophilicity in Micellar Enzymology,        3rdCRSI Symposium, Kolkata Chapter, Department of Chemistry, Indian Institute of Technology, Kharagpur, 6th August, 2005.

♦ A. Dasgupta, D. Das, R. N. Mitra, S. Roy, P. K. Das, Role of Microstructural Parameters in Micellar Enzymology, International Conference on Soft Matter, Park Hotel, Kolkata, 18th -20th November, 2004 –Poster.

CONTACT INFORMATION :

Tel: 0172 - 2210075
Email Id : sangita(at)inst(dot)ac(dot)in

Office Address :

Institute of Nano Science & Technology
Habitat Centre, Sector - 64, Phase X, Mohali