INST Faculty Directory
image galleries lightboxby VisualLightBox.com v5.7

Dr.Sharmistha Sinha

Assistant Professor (Scientist E)
Educational and Other Qualification:

Education: 2006 PhD (Biophysics), Molecular Biophysics Unit, Indian Institute of Science, Bangalore, INDIA.

Awards and Distinction:

♦ Recipient of the INSA Medal for Young Scientist 2008, Indian National Science Academy, Government of India.

♦Recipient of the SERB Women Excellence Award, 2017, Department of Science and Technology, Government of India

Positions held:

♦ Postdoctoral Fellow, Dept. of Biochem. Biophys. and Mol. Biol., Iowa State University, Ames, USA from 2010-2013
♦ Postdoctoral  Fellow, Dept. of Neurology, University of California, Los Angeles, USA from 2008-2010
♦ Research Associate, Indian Institute of Science, Bangalore, India from 2007-2008.

Research interests

♦ Biomaterials based on Prokaryotic Protein Assemblies
♦ Ligand-Protein interactions
♦ Protein Structure-Function relationship
♦ Genetic engineering of prokaryotic macromolecular assemblies

Recent Publications

8. Nanoparticle Fabrication on Bacterial Microcompartment Surface for the Development of Hybrid Enzyme-Inorganic Catalyst. Naimat Kalim Bari , Gaurav Kumar, Aashish Bhatt, Jagadish Prasad Hazra, Ankush Garg, Md. Ehesan Ali, Sharmistha Sinha* ACS Catal., 2018, 8, pp 7742–7748. https://pubs.acs.org/doi/10.1021/acscatal.8b02322

7. Cellulose-metallothionein matrix for metal binding. Naimat K.Bari, Shaswat Barua, Ankush Garg, Malay K.Sannigrahi, Sharmistha Sinha*. Carbohydrate Polymer 192, 2018, Pages 126-134. https://doi.org/10.1016/j.carbpol.2018.03.043

6. Enhanced bacterial cellulose production from Gluconobacter xylinus using super optimal broth. Prathna T. Chandrasekaran, Naimat Kalim Bari, Sharmistha Sinha*, Cellulose 24(10) , pp 4367–4381. https://link.springer.com/article/10.1007/s10570-017-1419-2

5.Selective molecular transport through the protein shell of a bacterial microcompartment organelle. Chowdhury C, Chun S, Pang A, Sawaya MR, Sinha S, Yeates TO, Bobik TA. Proc Natl Acad Sci U S A. 2015 ;112(10):2990-5. https://doi.org/10.1073/pnas.1423672112

4. Diverse bacterial microcompartment organelles. Chowdhury C, Sinha S, Chun S, Yeates TO, Bobik TA. Microbiol Mol Biol Rev. 2014;78(3):438-68. http://mmbr.asm.org/content/78/3/438.long

3.Alanine scanning mutagenesis identifies an asparagine-arginine-lysine triad essential to assembly of the shell of the Pdu microcompartment. Sharmistha Sinha, Shouqiang Cheng, Yea Won Sung, Dan E. McNamara, Michael R. Sawaya, Todd O. Yeates, Thomas A. Bobik. J. Mol. Biol. 2014 26(12):2328-45. https://doi.org/10.1016/j.jmb.2014.04.012

2. A Key Role for Lysine Residues in Amyloid β-Protein Folding, Assembly, and Toxicity Sharmistha Sinha, Dahabada H. J. Lopes, and Gal Bitan. ACS Chem. Neurosci., 2012, 3 (6), pp 473–481. https://pubs.acs.org/doi/10.1021/cn3000247

1. Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins. Sharmistha Sinha, Dahabada H. J. Lopes, Zhenming Du, Eric S. Pang, Akila Shanmugam, Aleksey Lomakin, Peter Talbiersky, Annette Tennstaedt, Kirsten McDaniel, Reena Bakshi, Pei-Yi Kuo, Michael Ehrmann, George B. Benedek, Joseph A. Loo, Frank-Gerrit Klärner, Thomas Schrader, Chunyu Wang, and Gal Bitan J. Am. Chem. Soc., 2011, 133 (42), pp 16958–16969. https://pubs.acs.org/doi/10.1021/ja206279b

Book Chapters:

♦ Amyloids and Protein Aggregation—Analytical Methods.   Li H, F Rahimi, K Murakami, SSinha, P Maiti, G Bitan. Encyclopedia of Analytical Chemistry. 2009
♦ Application of Photochemical Cross-linking to the Study of Oligomerization of Amyloidogenic Proteins. Lopes DHJ, S Sinha, C Rosensweig, G Bitan. Methods Mol Biol. 849:11-21.2012

Patents :

Sinha,S., P. Talbiersky, A. Lomakin, F.-G. Klärner, T. Schrader, S. Frautschy, and G. Bitan. International Patent Application No. PCT/US2010/026419, titled "Molecular Tweezers for the Treatment of Amyloid-Related Diseases". (Pending)
♦ T Schrader, K Hochdorffer, J Marz-Berberich, L Nagel-Steger, G Bitan, S Sinha. International Patent Application No. PCT/EP2010/000437, titled “New compounds for the treatment of diseases related to protein misfolding”

Conferences/Talks :

♦ The 56th Biophysical Society Meeting held at SanDiego, CA 2012.
♦ The 23rd Symposium of the Protein Society, Boston, MA 2009.
♦ XVIII International Symposium on Glycoconjugates (GLYCO-18), Florence, Italy, 2005.
♦ XVII International Symposium on Glycoconjugates (GLYCO-17), Bangalore, 2002

CONTACT INFORMATION :

Tel: 0172 - 2210075
Email Id : sinhas(at)inst(dot)ac(dot)in

Office Address :

Institute of Nano Science & Technology
Habitat Centre, Sector - 64, Phase X, Mohali