INST Faculty Directory
Dr. Subhasree Roy Choudhury
Scientist B
Educational Qualification:

2002-2007 Ph.D. from University of Calcutta, India (Subject: Physiology; awarded 2009)
SLET 2002 and GATE 2002 Qualified
2001 M.Sc. from University of Calcutta, India (Subject: Physiology).
1999 B.Sc. from University of Calcutta, India (Subject: Physiology) (Honors), Chemistry, Zoology.

Positions Held ::

2012-2014: Post Doctoral Fellow, The School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, QLD 4102, Australia.
2010-2011: Post Doctoral Fellow, Department of Biochemistry & Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. 
2008-2010: Post Doctoral Fellow, Department of Pathology, Microbiology and Immunology, University of South Carolina, Columbia, SC 29209, USA.
2007: Post Doctoral Fellow, Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA.

Awards ::

Awarded Gold Medal by University of Calcutta for securing the 1st Class 1st rank in M.Sc Physiology in 2001.
Awarded with Dr. D.N. Mallick Memorial Gold Medal by the Physiological Society of India for securing the 1st Class 1st rank in M.Sc Physiology in 2001.
Awarded with Prof. A. K. Mukherjee Memorial Cup by the 6th Annual Scientific Meet Committee, Calcutta in B.Sc examination in Physiology in 1999.
Awarded National Scholarship by the West Bengal Board of Secondary Education in Madhyamik examination in 1994.
Awarded Junior Research Fellowship and Senior Research Fellowship by UGC.

Research interests :

Development of target specific nanotherapeutics for epigenetic regulation of cancer. Chemoprevention and mechanism of action of drug/siRNA loaded nanoparticle mediated therapy for leukemia, neuroblastoma and glioblastoma. New drug development from natural products and combination therapy against cancer. Development and application of high-throughput functional gene-based screening for cancer. Multiple retrovirus and lentivirus mediated gene delivery for target validation and functional implication in cancer.

Selected Publications :

• Choudhury SR, Karmakar S, Banik NL, Ray SK (2012) Targeting Angiogenesis for Controlling     Neuroblastoma, J Oncol. 2012:782020. PMID: 21876694.
• Choudhury SR, Balasubramanian S, Chew Yap, Han B, Marquez V, Eckert RL (2011) Epigallocathechin-3-gallate and DZNep reduce polycomb protein level via a proteasome-dependent mechanism in skin cancer cells. Carcinogenesis, 32, 1525-32. PMID: 21798853.
• Choudhury SR, Karmakar S, Banik NL, Ray SK (2011) Valproic Acid Induced Differentiation and Potentiated Efficacy of Taxol and Nanotaxol for Controlling Growth of Human Glioblastoma LN18 and T98G Cells, Neurochem Res 36:2292-305. PMID: 21786169.
Karmakar S, Choudhury SR, Banik NL, Ray SK (2011) N-(4-Hydroxyphenyl) Retinamide Potentiated Anti-Tumor Efficacy of Genistein in Human Ewing’s Sarcoma Xenografts. World J Oncol 2:53-63. PMID:21822457.
Karmakar S, Choudhury SR, Banik NL, Ray SK (2011) Induction of Mitochondrial Pathways and Endoplasmic Reticulum Stress for Increasing Apoptosis in Ectopic and Orthotopic Neuroblastoma Xenografts. J  Cancer Ther, 2, 77-90. PMID:22468231
Karmakar S, Choudhury SR, Banik NL and Ray SK (2011) Molecular Mechanisms of the Anti-cancer Action of Garlic Compounds in Neuroblastoma cells. AntiCancer Agents in Medicinal Chemistry 11(4):398-407. PMID: 21521157.
Choudhury SR, Karmakar S, Banik NL, Ray SK (2010) Down regulation of angiogenic and survival factors increased apoptosis through upregulation of p53 and p21 in malignant neuroblastoma cells having N-Myc amplification or non-amplification. Investigational New Drugs 28:812-24. PMID: 19777160.
Karmakar S, Choudhury SR, Banik NL, Ray SK (2010) Activation of Multiple Molecular Mechanisms for Increasing Apoptosis in Human Glioblastoma T98G Xenograft. J Cancer Sci Ther 2: 107-113. PMID: 21666767.
Karmakar S, Choudhury SR, Banik NL, Ray SK (2009) Combination of N-(4-hydroxyphenyl) retinamide and genistein increased apoptosis in neuroblastoma SK-N-BE2 and SH-SY5Y xenografts. Neuroscience 163:286-295. PMID: 19540315.
Karmakar S, Davis KA, Choudhury SR, Deeconda A, Banik NL, Ray SK (2009) Bcl-2 inhibitor and apigenin worked synergistically in human malignant neuroblastoma cell lines and increased apoptosis with activation of extrinsic and intrinsic pathways. BBRC 388:705-710. PMID: 19695221.
Nishant Mohan, Surajit Karmakar, Choudhury SR, Naren L. Banik, and Swapan K. Ray (2009) Bcl-2 inhibitor HA14-1 and genistein together adeptly down regulated survival factors and activated cysteine proteases for apoptosis in human malignant neuroblastoma SK-N-BE2 and SH-SY5Y cells. Brain Res 1283:155-166. PMID: 19505441.
• A Gomes, Choudhury SR, A Saha, R Mishra, B Giri, AK Biswas, A Debnath, A Gomes (2007) A heat stable protein toxin (drCT-I) from the Indian Viper (Daboia russelli russelli) venom having antiproliferative, cytotoxic and apoptotic activities. Toxicon, 49(1), 46-56. PMID: 17055549.
Choudhury SR, Aparna Gomes, Antony Gomes, Jiban K. Dattagupta and Udayaditya Sen (2006) Purification, crystallization and preliminary X-ray structural studies of a 7.2 kDa cytotoxin isolated from the venom of Daboia russelli russelli of the Viperidae family. Acta Cryst. F62, 292–294. PMID: 16511326.
.B.Bishayi, S Roy Chowdhury, S.Ghose & M.Sengupta (2002) Hepatoprotective and Immunomodulatory properties Of Tinospora cordifolia in CCL4 intoxicated mature albino rats. The Journal Of Toxicological Science, 27(3), 139-146. PMID: 12238138.

Book Chapter :

Roy Choudhury S, Karmakar S, Banik NL, Ray SK (2010) Role of angiogenesis in the pathogenesis of glioblastoma and antiangiogenic therapies for controlling glioblastoma. In Glioblastoma: Molecular Mechanisms of Pathogenesis and Current Therapeutic Strategies. Publisher: Springer; 1 edition, Page: 217-241, ISBN-978-1-4419-0409-6.

Conference :

Roy Choudhury Subhasree, and Gonda Tom (2014) Functional validation of Myb target genes in myeloid leukaemic transformation. New directions in leukemia research. March 30-April 2nd, Noosa, QLD, Australia.
Ding Jianmin, Roy Choudhury Subhasree, Cao Lu, and Gonda Tom (2014) c-Myb interaction with histone acetyltransferase p300 regulates its transcriptional activities in human leukaemic cells. New directions in leukemia research. March 30-April 2nd, Noosa, QLD, Australia.
Davis KA, Karmakar S, Choudhury SR, Banik NL and Ray SK (2010) Synergistic efficacy of HA14-1 and apigenin in inhibiting angiogenic factors and increasing apoptosis in neuroblastoma cells. Frontiers in Neuroscience Conference. March 05 - 07, 2010, Atlanta, USA.
Roy Choudhury S, Karmakar S, Banik NL, Ray SK (2009) Combination of valproic acid and taxol or nanotaxol induced differentiation and apoptosis in glioblastoma LN18 and T98G cells presented at the 40th Annual ASN Meeting, Charleston, SC - March 7-11 2009.
Roy Choudhury S, Karmakar S, Banik NL, Ray SK (2009) Combination of sorafenib and genistein inhibits angiogenesis and triggers multiple molecular mechanisms for apoptosis in human malignant neuroblastoma SK-N-DZ and SH-SY5Y cell lines presented at the 100th AACR Annual Meeting Denver, CO, April 18-22, 2009.
Mohan N, Karmakar S, Roy Choudhury S, Banik NL , Ray SK (2009) Small Molecule Inhibitor of Bcl-2 Enhances Efficacy of Genistein for Apoptosis in Neuroblastoma SH-SY5Y and SK-N-BE2 Cell lines. Presented at the 40th Annual ASN Meeting,Charleston, SC - March 7-11, 2009.
Davis K, Karmakar S, Roy Choudhury S, Deeconda A, Banik NL, Ray SK (2009) Combination of Bcl-2 inhibitor and apigenin activated extrinsic and intrinsic pathways of apoptosis in neuroblastoma SK-N-DZ cells. Presented at the 40th Annual ASN Meeting, Charleston, SC - March 7-11, 2009.
Karmakar S, Roy Choudhury S, Tomlinson S, Banik NL, Ray SK (2009) Combination of N-(4-hydroxyphenyl) retinamide and genistein increases apoptosis in Ewing’s sarcoma SK-N-MC cells in culture and xenografts in athymic nude mice. Presented at the 100th AACR Annual Meeting Denver, CO, April 18-22, 2009.
Karmakar S, Roy Choudhury S, Banik NL, Ray SK (2009) Activation of both extrinsic and intrinsic pathways of apoptosis in human neuroblastoma SH-SY5Y cells in culture as well as in xenografts in athymic nude mice. Presented at the 40th Annual ASN Meeting, Charleston, SC - March 7-11 2009.
• Roy Choudhury S, Karmakar S, Banik NL, Ray SK (2009) Combination of valproic acid and taxol or nanotaxol effectively inhibited angiogenic factors and increased apoptosis in glioblastoma U87MG cells in culture and xenografts in nude mice. Presented at the 40th Annual ASN Meeting, Charleston, SC - March 7-11 2009.
Dasgupta SC, Saha A, Giri B, Choudhury SR, Gomes A (2006) A new protein toxin (drCT1) from Dabuia russellii venom having antiproliferative and apoptogenic activity in15th World Congress on Animal, Plant & Microbial Toxins, International Society on Toxinology, Glasgow, UK. July 27.
• Choudhury SR, Gomes A (2005) Antineoplastic protein toxin (Toxin CM28) from Vipera russelli russelli venom38th Annual Conference of the Indian Pharmacological Society, Chennai, December 28-30.
• Choudhury SR, Gomes A (2005) Structure and functional characterization of a heat stable antineoplastic protein toxin (Toxin CM28) from Russells viper venom.  37th Annual Conference of the Indian Pharmacological Society, Kolkata, January 14-16.
• Choudhury SR, Gomes A (2003) Pharmacological characterization of a heat stable protein toxin (Toxin CM 28) from Russells viper venom CM 28) from Russells viper venom.  36th Annual Conference of the Indian Pharmacological Society, Delhi, December, 5-7.
• Choudhury SR, Bishayi B (2002) Hepatoprotective, immunostimulatory and antioxidant activities of Tinospora cordifolia in CCL4 intoxicated mature albino rats. XIII Annual Conference of the Physiological Society of India, Kolkata, February 23-24.

 

CONTACT INFORMATION :

Tel: 0172 - 2210075
Email Id : subhasreerc(at)inst(dot)ac(dot)in

Office Address :

Institute of Nano Science & Technology
Habitat Centre, Sector - 64, Phase X, Mohali