Faculty Directory

Dr. Jayamurugan Govindasamy

Associate Professor (Scientist-E)

New synthetic methods, Functional organic materials, Supramolecular chemistry, Polymer chemistry. The research in my group is centred on synthetic organic chemistry with a view to exploring nanoporous and nanomaterials for various types of applications ranging from energy, catalysis, sensing, and Nanotherapeutics. Thus, it is highly interdisciplinary in nature. The general strategy of our research is designing and synthesizing the functional nanomaterials with targeted applications and understanding the properties by applying state-of-the-art characterization techniques.

CONTACT INFORMATION :

Research Interest

  • Donor-Acceptor Compounds: Synthesis and studies of new class of potential push-pull chromophores for optoelectronic, sensing, and high energy related applications.
  • Framework Materials: Synthesis and studies of porous covalent-organic (COF) and metal-organic framework materials (MOF) based on supramolecular chemistry approach and its applications in view of energy storage, catalysis, bio-sensing, and photovoltaic applications.
  • Functional Nanomaterials: Development of new methods for the synthesis of highly branched functional nanomaterials as smart vehicles for Drug/Antibody/Gene delivery applications with following goals of cheap, easy to synthesis and versatile system.

Research Highlights

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PhD Students

  • Mr. Arif Hassan Dar

    Email: arif.ph15216@inst.ac.in

    Reg. No.: Ph15216

    Working Since Jan, 2016
  • Ms. Neethu K M

    Email: neethu.rp251722@inst.ac.in

    Reg. No.: PH251722

    Working Since Jan, 2018
  • Mr. Abdul Selim

    Email: abdul.ph16219@inst.ac.in

    Reg. No.: PH16219

    Working Since Jul, 2016
  • Ms. Shaifali Sartaliya

    Email: shaifali.ph16232@inst.ac.in

    Reg. No.: PH16232

    Working Since Jan, 2017

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  1. Tuning of the Cross-Glaser Products mediated by Substrate-Catalyst’s Polymeric Backbone Interactions: S. Kuar, A. Mukhopadhyaya, A. Selim, V. Gowri, K. M. Neethu, A. H. Dar,S. Sartaliya, M. E. Ali*, G. Jayamurugan*, (2020) Chem. Commun., 56: 2582-2585. DOI: 10.1039/C9CC08565C

  2. Hyperbranched polymer-functionalized magnetic nanoparticles mediated hyperthermia and niclosamide bimodal therapy of Colorectal Cancer Cells.: A Ahmad, A Gupta, MM Ansari, A Vyawahare, G Jayamurugan,R. Khan*, (2019) ACS Biomater. Sci. Eng., 6: 1102-1111. DOI: 10.1021/acsbiomaterials.9b01947

  3. Designing of Push-Pull Chromophores with Tunable Electronic and Luminescent Properties using Urea as Electron Donor: A. H. Dar, V. Gowri,A. Gopal, A. Muthukrishnan, A. Bajaj, S. Sartaliya, A. Selim, M. E. Ali, G. Jayamjurugan*, (2019) The Journal of Organic Chemistry, 84: 8941 - 8947. DOI: 10.1021/acs.joc.9b00841

  4. Nanocarrier Composed of Magnetite Core Coated with Three Polymeric Shells Mediates LCS-1 Delivery for Synthetic Lethal Therapy of BLM-Defective Colorectal Cancer Cells: A. Gupta, A. AHMAD, H. Singh, S. Kaur, Neethu K M, M. M. Ansari, (2018) Biomacromolecules, 19: 803-815. DOI: 10.1021/acs.biomac.7b01607

  5. Design and Synthesis of Aviram–Ratner-Type Dyads and Rectification Studies in Langmuir–Blodgett (LB) Films: V. Gowri, D. Hernández, S. Martin, A. González-Orive, C. Dengiz, O. Dumele, F. Pérez-Murano, J.-P. Gisselbrecht, C. Boudon, W. B. Schweizer, B. Breiten, A. D. Finke, G. Jeschke, B. Bernet, L. Ruhlmann, P. Cea, F. Diederich, (2016) Chem. Eur. J., 22: 10539-10547. DOI: 10.1002/chem.201505216

  6. Size and Energy Level Tuning of Quantum Dot Solids via a Hybrid Ligand Complex: M. L. Böhm, T. C. Jellicoe, J. P. H. Rivett, A. Sadhanala, N. J. L. K. Davis, F. S. F. Morgenstern, K. C. Gödel, C. G. M. Benson, N. C. Greenham, B. Ehrler, (2015) J. Phys. Chem. Lett., 6: 3510−3514. DOI: 10.1021/acs.jpclett.5b01751

  7. Selective endo and exo binding of mono- and ditopic-ligands to a rhomboidal diporphyrin prism: D. A. Roberts, T. K. Ronson, J. R. Nitschke, (2015) Angew. Chem. Int. Ed., 54: 7539-7543. DOI: 10.1002/anie.201501359

  8. Enhancement of immunogenicity and efficacy of a plasmid DNA rabies vaccine by nanoformulation with a fourth-generation amine-terminated poly(ether imine) dendrimer: P. T. Ullas, S. N. Madhusudana, A. Desai,N. Jayaraman, (2014) Int. J. Nanomedicine, 9: 627–634. DOI: 10.2147/IJN.S53415

  9. One-Pot access to push-pull oligoenes by sequential [2+2] cycloaddition–retroelectrocyclization reactions: A. D. Finke, J.-P. Gisselbrecht, C. Boudon, W. B. Schweizer, F. Diederich, (2014) J. Org. Chem, 79: 426–431. DOI: 10.1021/jo402440m

  10. Expanding the chemical structure space of optoelectronic molecular materials: unprecedented push–pull chromophores by reaction of a donor-substituted tetracyanofulvene with electron-rich alky: O. Dumele, J.-P. Gisselbrecht, C. Boudon, W. B. Schweizer, B. Bernet, F. Diederich, (2013) J. Am. Chem. Soc., 135: 3599–3606.. DOI: 10.1021/ja312084s

  11. Photophysical behavior of poly(propyl ether imine) dendrimer in the presence of nitroaromatic compounds: R. S. Bagul, Y. B. R. D. Rajesh, A. Bera, A. K. Sood, N. Jayaraman, (2013) J. Photochem. Photobiol., A, 253: 1–6. DOI: 10.1016/j.jphotochem.2012.12.011

  12. 6,6-Dicyanopentafulvenes: Electronic structure and regioselectivity in [2 + 2] cycloaddition–retroelectrocyclization reactions: A. D. Finke, O. Dumele, M. Zalibera, D. Confortin, P. Cias, J.-P. Gisselbrecht, C. Boudon, W. B. Schweizer, G. Gescheidt, F. Diederich, (2012) J. Am. Chem. Soc, 134: 18139–18146. DOI: 10.1021/ja309141r

  13. Dendritic poly(ether imine) based gene delivery vector: U. P. Thankappan, S. N. Madhusudana, A. Desai, Y. B. R. D. Rajesh, N. Jayaraman, (2011) Bioconjugate Chem, 22: 115–119. DOI: 10.1021/bc1003108

  14. Expanding the chemical space for push-pull chromophores by non-concerted [2+2] and [4+2] cycloadditions: access to a highly functionalized 6,6-dicyanofulvene with an intense low-energy charge: J.-P. Gisselbrecht, C. Boudon, F. Schoenebeck, W. B. Schweizer, B. Bernet, F. Diederich, (2011) Chem. Commun., 47: 4520–4522. DOI: 10.1039/C1CC10247H

  15. Interaction of single-walled carbon nanotubes with poly(propyl ether imine) dendrimers: K. S. Vasu, Y. B. R. D. Rajesh, S. Kumar, V. Vasumathi, P. K. Maiti, A. K. Sood, N. Jayaraman, (2011) J. Chem. Phys., 134: 104507/1–104507/6. DOI: 10.1063/1.3561308

  16. Preparation and catalytic studies of palladium nanoparticles stabilized by a dendritic ligand-functionalized Silica: C. P. Umesh, N. Jayaraman, (2009) J. Mol. Catal. A: Chem, 307: 142–148. DOI: 10.1016/j.molcata.2009.03.020

  17. Increased efficacies of an individual catalytic site in clustered multivalent dendritic catalysts: N. Jayaraman, (2009) Adv. Synth. Catal., 351: 2379–2390. DOI: 10.1002/adsc.200900377

  18. Inherent photoluminescence properties of poly(propyl ether imine) dendrimers: C. P. Umesh, N. Jayaraman, (2008) Org. Lett., 10: 9–12. DOI: 10.1021/ol702635w

  19. Structure of poly(propyl ether imine) dendrimer from fully atomistic molecular dynamics simulation and by small angle X-ray scattering: R. Ganapathy, P. K. Maiti, N. Jayaraman, A. K. Sood,C. Jana, (2006) J. Chem. Phys., 124: 204719/1–204719/10. DOI: 10.1063/1.2194538

  20. Synthesis of large generation poly(propyl ether imine) (PETIM) dendrimers: N. Jayaraman, (2006) Tetrahedron, 62: 9582–9588. DOI: 10.1016/j.tet.2006.07.094

  1. Tuning of the Cross-Glaser Products mediated by Substrate-Catalyst’s Polymeric Backbone Interactions: S. Kuar, A. Mukhopadhyaya, A. Selim, V. Gowri, K. M. Neethu, A. H. Dar,S. Sartaliya, M. E. Ali*, G. Jayamurugan*, (2020) Chem. Commun., 56: 2582-2585. DOI: 10.1039/C9CC08565C

  1. Dendrimer-metal nanocomposites and their optical behavior: In Nanotechnological Applications of Novel polymers; Adeli, M., Ed.; Transworld Research Network: Trivandrum, B. M. Kiran,N. Jayaraman, (2009) 105–131.

  1. Poly(ether imine) dendrimers and uses thereof: Indian pat. Appl. IN2010CH04010, N. Jayaraman, (2014) 64.

  2. “New poly(ether imine) dendrimers useful in preparing polymer system for deleivering negatively charged moleucle e.g. nucliec acid, DNA, polynucleotides, short interfering RNA, micro RNA and : PCT Int. Appl. WO 2012090223-A1 N. Jayaraman, P. U. Thankappan, N. S. Madhusudana, A. Desai,Yamajala B. R. D. Rajesh, (2012) .

  3. A method for detecting an analyte: US patent App, US 20120171776 N. Jayaraman,Y. B. R. D. Rajesh, R. Bhaskara, B. Suresh, A. K. Sood, (2011) 18.

  1. Applying synthetic lethality to nanomedicine: LCS-1 loaded magnetite and polymeric nanoparticles for the treatment of BLM and CHEK2-deficient colorectal cancer cells: In CANCER MEDICINE 111 RIVER ST, HOBOKEN 07030-5774, NJ USA: WILEY A. Gupta, Ahmad A, (2018) 7: 27-28.

  2. CuI/IIO Nanoparticles-Grafted Tailor-made Cellulose as an Efficient Catalyst for “Glaser” Homo- and Hetero-coupling Reactions “First INST-CeNS Joint symposium,: Hampi, (2017) .

  3. Customized Nanocarrier for Therapeutic Targeting of Cancer Cells, DBT workshop for biotechnology school: organized by INST at NABI, (2017) .

  4. Biocompatible hyperbranched polymers coated magnetite nanocarrier for therapeutic targeting of cancer cells National Conference on Trends in Nanobiotechnology (NCTN-2016): CCS Haryana Agricultural University, Hisar, India, (2016) .

  5. Fulvenoid, nonplanar push-pull chromophores: Poster presentation at the Electronic Process in Organic Materials Gordon Conference, Lucca, Italy, J.-P. Gisselbrecht, C. Boudon, W. B. Schweizer, F. Diederich,A. D. Finke, O. Dumele, (2012) .

  6. Swiss Chemical Society: ETH-Zurich / Switzerland _ Poster: “Diverse Chemical Reactivity of Push-Pull type Fulvene with Electron Rich Alkynes O. Dumele, W. B. Schweizer, B. Bernet, J.-P. Gisselbrecht, C. Boudon, F. Diederich, (2011) .

  7. Wisenshaftforumchemie: Expanding the Chemical Space for Push-Pull chromophores by Non-concerted [2+2] and [4+2] Cycloadditions: Access to a Highly Functionalized 6,6-dicyanopentafulvene with Attractive Opto-electronic Properties F. Schoenebeck, W. B. Schweizer, B. Bernet, J.-P. Gisselbrecht, C. Boudon, F. Diederich, (2011) .

  8. 3rd EuCheMS Chemistry Congress: Nürnberg / Germany _ Poster: “Synthesis and Studies of Chiral and Achiral Push-Pull Type Charge-Transfer Chromophores Derived from Different Oligoyne” B. B. Frank, M. Kivala, W. B. Schweizer, B. C. Blanco, B. Breiten, R. R. Tykwinski, E. Jahnke, C. Boudon, J.-P. Gisselbrecht, F. Diederich, (2010) .

  9. Synthesis and Studies of Poly(Ether Imine) (PETIM) Dendritic Macromolecules: National Conference on Chemistry,Bangalore University, Bangalore, India. N. Jayaraman, (2006) .

  10. International Symposium in Organic Chemistry: IISc, Bangalore, India _ Poster Presentation: “Synthesis and Fluorescence Studies of Poly(Propyl Ether Imine) (PETIM) Dendrimers”. N. Jayaraman, (2005) .

Fundings

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  • 2009

    Ph.D

    Department of Organic Chemistry, Indian Institute of Science (IISc), Bangalore, India

  • 2003

    M.Sc

    Organic Chemistry (specialization), University of Madras, Chennai, India

  • 2001

    B.Sc

    University of Madras, India

  • Assistant Professor (Scientist-D):Institute of Nano Science and Technology,, Mohali, India (June 2015 to Present till date )

  • Postdoctoral Research Associate:University of Cambridge,, United Kingdom. (January 2013 to May 2015 )

  • Postdoctoral Fellow:ETH-Zurich, . (PI: Prof. François Diederich), Switzerland (January 2010 to December 2012 )

  • Research Associate:Indian Institute of Science, (PI: Prof. N. Jayaraman), Bangalore, India (April 2009 to December 2009 )

Awards & Honours

  • Ramanujan Fellowship awarded by DST-SERB-five year research grant (2016-2021)
  • Early Career Research (ECR) Award by SERB-three year research grant (2016-2019)
  • Two and half year’s post-doctoral fellowship sponsored by EPSRC at University of Cambridge.(2012)
  • Three years post-doctoral fellowship sponsored by European Research Council (ERC) at ETH-Zurich.(2010)
  • Awarded Senior Research Fellowship (SRF) by Council of Scientific Industrial Research.(2005)
  • Secured second place in State level inter collegiate P. G. quiz competition.(2003)
  • Qualified in national eligibility test “CSIR-NET-2003”. Awarded Junior Research Fellowship (JRF) by Council of Scientific Industrial Research
  • Secured 95.5 percentile in national level Graduate Aptitude Test in Engineering “GATE-2002”

Professional Recognitions