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Dr. Prakash P. Neelakandan :(Head of Unit)

Scienctist 'F' (Head of Unit)

Our research group is focused on using synthetic organic chemistry to prepare new organic functional materials for applications in flexible electronic devices, sensors and cancer therapeutics.

Contact Information :

  • Photoactive Organic Soft Materials


    Our research group is focused on using synthetic organic chemistry to prepare new organic compounds and their composite materials. We have well-established laboratories and instrumentation facilities for the synthesis, characterization and studying the photochemical and photophysical properties of the newly synthesized functional materials.


    The major ongoing projects include studying plasmon-molecule coupling in organic dye loaded metal nanoparticles, development of flexible organic single crystals, synthesis of novel luminescent organic materials and DNA analogues. These materials are then explored for applications in various fields ranging from cancer therapeutics to sensors and flexible electronic devices.

  • Highly sensitive chemosensors have been developed for biologically relevant thiols and fluoride anions.
    Organic single crystals showing flexible optical waveguide and thermosalience have been developed.
    Our recent results help to understand the role of chemical structure in plasmon-molecule coupling.
    Dye-loaded metal nanoparticles find application as PDT and cellular imaging agents.

Current Group Members

  • PRODIPTA SAMADDER

    PRODIPTA SAMADDER

    Email: prodipta.ph23211@inst.ac.in

    Reg. No.: PH23211

  • AJAY KUMAR

    AJAY KUMAR

    Email: ajay.ph21244@inst.ac.in

    Reg. No.: PH21244

  • KIRAN ARORA

    KIRAN ARORA

    Email: kiran.ph21242@inst.ac.in

    Reg. No.: PH21242

  • HEMANT

    HEMANT

    Email: hemant.ar210106@inst.ac.in

    Reg. No.: 10BB21J67006

  • AYUSHI NAGPAL

    AYUSHI NAGPAL

    Email: ayushi.ph20232@inst.ac.in

    Reg. No.: PH20232

  • PINKI

    PINKI

    Email: pinki.rp942322@inst.ac.in

    Reg. No.: RP942322

  • PRODIPTA SAMADDER

    PRODIPTA SAMADDER

    Email: prodipta.rp942121@inst.ac.in

    Reg. No.: RP942121

Alumni

  • PARVATI MARANDI

    PARVATI MARANDI

    Reg. No.: PH17218

    Designation: PhD Scholar

    Jan 2018 - Oct 2023

  • SANCHITA SHAH

    SANCHITA SHAH

    Reg. No.: PH16229

    Designation: PhD Scholar

    Jan 2017 - Jun 2023

  • ATIKUR RAHMAN

    ATIKUR RAHMAN

    Reg. No.: RA-01-202149

    Designation: Post Docs/RA

    Sep 2022 - Nov 2023

  • SUMAN R. MALLAH

    SUMAN R. MALLAH

    Reg. No.: RP261823

    Designation: Project JRF/SRF

    Jan 2018 - Feb 2019

  • P. P. PRAVEEN KUMAR

    P. P. PRAVEEN KUMAR

    Reg. No.: NPDF1709

    Designation: Post Docs/RA

    Oct 2017 - Jan 2020

  • 1.

    Multifunctional BODIPY Embedded Non-woven Fabric for CO Release and Singlet Oxygen Generation: , S Shah, N Naithani, SC Sahoo, PP Neelakandan*, N Tyagi* , 2022 , J. Photochem. Photobiol. B Biology, -: - , 10.1016/j.jphotobiol.2022.112631
  • 2.

    Plasmonically active supramolecular polymer-metal organic framework hydrogel nanocomposite for localized chemo-photothermal therapy: , Navneet Kaur, Mimansa, Priyanka Sharma, Panangattukara Prabhakaran Praveen Kumar, Prakash P. Neelakandan, Asifkhan Shanavas , (2022) , ACS Applied Polymer Materials , 10.1021/acsapm.2c01646
  • 3.

    Molecular Logic Operations using Multi-stimuli Responsive, Mechanically Tunable Elastic Organic Single Crystals: , P Marandi, K Naim, K Parida, PP Neelakandan* , (2022) , 4: 2499-2505 , ACS Mater. Lett. , 10.1021/acsmaterialslett.2c00889
  • 4.

    Hot Electron Migration from Gold Nanoparticle to an Organic Molecule Enhances Luminescence and Photosensitization Properties of a pH Activatable Plasmon-Molecule Coupled Nanocomposite: , A Rahman, T Goswami, N Tyagi, HN Ghosh*, PP Neelakandan* , (2022) , 432: 114067 , J. Photochem. Photobiol. A: Chem , 10.1016/j.jphotochem.2022.114067
  • 5.

    Isomer Selective Thermosalience and Luminescence Switching in Organic Crystals: , K Naim, SC Sahoo,PP Neelakandan* , (2022) , 14: 22650-22657 , ACS Appl. Mater. Interfaces , 10.1021/acsami.2c05053
  • 6.

    Gold–BODIPY Nanoparticles with Luminescence and Photosensitization Properties for Photodynamic Therapy and Cell Imaging: , A Rahman, PPP Kumar, P Yadav, T Goswami, A Shanavas*, HN Ghosh*, PP Neelakandan* , (2022) , 5: 6532-6542 , ACS Appl. Nano Mater. , 10.1021/acsanm.2c00616
  • 7.

    Aggregation-Induced Emission, Mechanofluorochromism, and Selective Fluoride Detection by a Tripodal Salicylaldimine: , P Marandi,N Tyagi,PP Neelakandan* , (2022) , 87: e202100555 , ChemPlusChem , 10.1002/cplu.202100555
  • 8.

    Fine‐Tuning Plasmon‐Molecule Interactions in Gold‐BODIPY Nanocomposites: The Role of Chemical Structure and Noncovalent Interactions: , PPP Kumar, A Rahman, T Goswami, HN Ghosh*, PP Neelakandan* , (2021) , 86: 87-94 , ChemPlusChem , 10.1002/cplu.202000545
  • 9.

    Remarkable Self-assembly of Salicylideneimine-Boron Complexes into Plastic Crystals and Organogels: , K Naim, SC Sahoo, P Venugopalan, PP Neelakandan* , (2021) , 21: 3798-3806 , Cryst. Growth Des. , 10.1021/acs.cgd.1c00132
  • 10.

    Advances in the Supramolecular Chemistry of Tetracoordinate Boron-containing Organic Molecules into Organogels and Mesogens: , S Shah, P Marandi, PP Neelakandan* , (2021) , 9: 708854 , Front. Chem. , 10.3389/fchem.2021.708854
  • 11.

    Exceptionally Plastic/Elastic Organic Crystals of a Naphthalidenimine‐Boron Complex Show Flexible Optical Waveguide Properties: , K Naim, M Singh, S Sharma, RV Nair, P Venugopalan*, SC Sahoo*, PP Neelakandan* , (2020) , 26: 11979-11984 , Chem. Eur. J. , 10.1002/chem.202002641
  • 12.

    Synthesis and Anti‐Proliferative Activity of a Triazole‐Fused Thymidine Analogue: , A Rahman, P Sharma, N Kaur, A Shanavas*, and PP Neelakandan* , (2020) , 5: 5473-5478 , ChemistrySelect , 10.1002/slct.202001013
  • 13.

    Aggregation Enhances Luminescence and Photosensitization Properties of a Hexaiodo-BODIPY: , PPP Kumar, P Yadav, A Shanavas, and PP Neelakandan* , (2020) , 4: 965-972 , Mater. Chem. Front. , 10.1039/D0QM00010H
  • 14.

    Nanomolar Detection of Biothiols via Turn-ON Fluorescent Indicator Displacement: , PPP Kumar, N Kaur, A Shanavas, and PP Neelakandan* , (2020) , 145: 851-857 , Analyst , 10.1039/C9AN02222H
  • 15.

    Selective Metal-ion Detection and Activatable Photosensitization Properties of a Tetraphenylethylene based Salicylideneimine: , P Marandi, PPP Kumar, P Venugopalan, and PP Neelakandan* , (2019) , 4: 5707-5713 , ChemistrySelect , 10.1002/slct.201901035
  • 16.

    A Three-Component Supramolecular Nanocomposite as a Heavy-Atom-Free Photosensitizer: , PPP Kumar, P Yadav, A Shanavas, S Thurakkal, J Joseph, and PP Neelakandan* , (2019) , 55: 5623-5626 , Chem. Commun. , 10.1039/C9CC02480H
  • 17.

    Supramolecular confinement within chitosan nanocomposites enhance singlet oxygen generation: , K Naim, S T Nair, P Yadav,A Shanavas, P P Neelakandan , (2018) , 83: 418 –422. , ChemPlusChem , /10.1002/cplu.201800041
  • 18.

    Iodo-functionalized Salicylideneimine-Boron Complexes: Synthesis and Photosensitized Degradation of Organic Water Pollutants: , S Shah, A Bajaj, A Shibu, ME Ali*, and PP Neelakandan* , (2018) , 24: 18788-18794 , Chem. Eur. J. , 10.1002/chem.201804376
  • 19.

    Excitation energy delocalization and transfer to guests within M4L6 cage frameworks: , AJ Musser,† PP Neelakandan,† JM Richter, H Mori, RH Friend*, and JR Nitschke* , (2017) , 139: 12050-12059 , J. Am. Chem. Soc. , 10.1021/jacs.7b06709
  • 20.

    Simultaneous binding of a cyclophane and classical intercalators to DNA: Observation of FRET-mediated white light emission: , KS Sanju, S Thurakkal, PP Neelakandan, J Joseph, D Ramaiah* , (2015) , 17: 13495-13500 , Phys. Chem. Chem. Phys. , 10.1039/C5CP00208G
  • 21.

    Stimuli responsive metal-ligand assemblies: , AJ McConnell,† CS Wood,† PP Neelakandan,† JR Nitschke* , (2015) , 115: 7729-7793 , Chem. Rev , 10.1021/cr500632f
  • 22.

    An autocatalytic system of photooxidation-driven substitution reactions on a FeII4L6 cage framework: , PP Neelakandan, A Jiménez, JD Thoburn, JR Nitschke* , (2015) , 127: 14586-14590 , Angew. Chem. Int. Ed. , 10.1002/anie.201507045
  • 23.

    Ground and excited state electronic spectra of perylenediimide dimers with flexible and rigid geometries in DNA conjugates: , T. A Zeidan, M. McCullagh, G. C. Schatz, J. Vura-Weis, C. H. Kim, M. R. Wasielewski, F. D. Lewis , (2014) , 5: 973-981 , Chem. Sci. , 10.1039/C3SC52908H
  • 24.

    Fluorophore incorporation allows nanomolar guest sensing and white-light emission in M4L6 cage complexes: , PP Neelakandan, A Jiménez, JR Nitschke* , (2014) , 5: 908-915 , Chem. Sci. , 10.1039/C3SC53172D
  • 25.

    Interplay of monomer, intra- and intermolecular excimer fluorescence in cyclophanes and selective recognition of methanol vapours: , PC Nandajan, PP Neelakandan, D Ramaiah* , (2013) , 3: 5624-5630 , RSC Adv. , 10.1039/C3RA21678K
  • 26.

    Facially-selective thymine-thymine photodimerization in TTT triads: , PP Neelakandan, Z Pan, M Hariharan, FD Lewis* , (2012) , 11: 889-892 , Photochem. Photobiol. Sci. , C2PP25089F
  • 27.

    10.1039/C0CC04173D , PP Neelakandan, M McCullagh, GC Schatz, FD Lewis* , (2012) , 116: 5199-5204 , J. Phys. Chem. B , 10.1021/jp302385c
  • 28.

    DNA-assisted white light emission through FRET: , KS Sanju, PP Neelakandan, D Ramaiah* , (2011) , 47: 1288-1290 , Chem. Commun. , 10.1039/C0CC04173D
  • 29.

    Study of cavity size and nature of bridging units on recognition of nucleotides by cyclophanes: , PP Neelakandan, PC Nandajan, B Subymol, D Ramaiah* , (2011) , 9: 1021-1029 , Org. Biomol. Chem. , 10.1039/C0OB00673D
  • 30.

    Hydrophobic self-assembly of a perylenediimide-linked DNA dumbbell into supramolecular polymers: , PP Neelakandan, Z Pan, M Hariharan, Y Zheng, H Weissman, B Rybtchinski*, FD Lewis* , (2010) , 132: 15808-15813 , J. Am. Chem. Soc , 10.1021/ja1076525
  • 31.

    Functional cyclophanes: Promising hosts for optical biomolecular recognition: , D. Ramaiah*, PP Neelakandan, AK Nair, RR Avirah , (2010) , 39: 4158-4168 , Chem. Soc. Rev. , 10.1039/B920032K
  • 32.

    Effect of bridging units on photophysical and DNA binding properties of a few cyclophanes: , PP Neelakandan, KS Sanju, D Ramaiah* , (2010) , 86: 282-289 , Photochem. Photobiol. , 10.1111/j.1751-1097.2009.00660.x
  • 33.

    A supramolecular Cu(II) metallocyclophane probe for guanosine 5’-monophosphate: , AK Nair, PP Neelakandan, D Ramaiah* , (2009) , 2009: 6352-6354 , Chem. Commun. , 10.1039/B911855A
  • 34.

    DNA assisted long lived excimer formation in a cyclophane: , PP Neelakandan, D Ramaiah* , (2008) , 47: 8407-8411 , Angew. Chem. Int. Ed. , 10.1002/anie.200803162
  • 35.

    Encapsulation of electron donor-acceptor dyads in β-CD cavity: Unusual planarization and enhancement in rate of electron transfer reaction: , M Hariharan, PP Neelakandan, D Ramaiah* , (2007) , 111: 11940-11947 , J. Phys. Chem. B , 10.1021/jp074643d
  • 36.

    A supramolecular ON-OFF-ON fluorescence assay for selective recognition of GTP: , PP Neelakandan, M Hariharan, D Ramaiah* , (2006) , 128: 11334-11335 , J. Am. Chem. Soc , 10.1021/ja062651m
  • 37.

    Synthesis of a Novel Cyclic Donor−Acceptor Conjugate for Selective Recognition of ATP: , PP Neelakandan, M Hariharan, D Ramaiah* , (2005) , 7: 5765-5768 , Org. Lett. , 10.1021/ol052246k
  • 1.

    Photoactive Finite Supramolecular Coordination Cages for Photodynamic Therapy: , N Tyagi, PP Neelakandan* , (2022) , 2023: Elsevier , Supramolecular Coordination Complexes: Design, Synthesis, and Applications , ISBN: 9780323905824

  • INSPIRE Faculty Award by DST, Government of India in February 2013 (not availed).

    SERC Bio-inorganic Pre-doctoral Fellowship awarded by DST, Government of India in October 2006.

  • Postdoctoral Research Associate:University of Cambridge, UK (May 2012 to March 2015 )

  • Associate Professor (Scientist E):Institute of Nano Science and Technology, Mohali, India. (April 2015 to December 2020 )

  • Professor (Scientist F):Institute of Nano Science and Technology, Mohali, India. (January 2021 to Present till date )

  • Postdoctoral Fellow:Northwestern University, Evanston, IL, USA. (July 2009 to April 2012 )

  • Title: Organoboron Macrocycles as Adaptable, Photoactive Materials

    PI: Dr. Prakash P. Neelakandan

    Tenure: 3 years

    End Date: 02-Dec-2019

    Funding Agency: SERB

  • Title: Dynamic Self-assembled Nucleic Acid Analogues

    PI: Dr. Prakash P. Neelakandan

    CO-PI: Dr. Asifkhan Shanavas

    Tenure: 3 years

    End Date: 21-Feb-2021

    Funding Agency: DBT

  • Title: Photoactive Organoboron Macrocycles for Sensing and Optoelectronic Applications

    PI: Dr. Prakash P. Neelakandan

    Tenure: 3 years

    End Date: 01-Sep-2024

    Funding Agency: CSIR

  • Title: Luminescent Organic Single Crystals for Flexible Display Devices

    PI: Dr. Prakash P. Neelakandan

    CO-PI: Dr. Kaushik Parida

    Tenure: 3 years

    End Date: 01-Feb-2026

    Funding Agency: SERB

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