Nanoparticle surface chemistry and Hemolysis
Navneet Kaur et al studied high and low molecular weight PLGA nanoparticles with glycol chitosan and carboxymethyl chitosan coating Glycol chitosan reduced Extraneous Paclitaxel Precipitates (EPPs) during LMW PLGA nanoprecipitation for uniform intracellular drug delivery. Molecular weight wise composition of protein corona varied distinctly between glycol chitosan and carboxymethyl chitosan coatings. Glycol chitosan-coated nanoparticles fared better in terms of compatibility with RBC in its nascent form irrespective of its positive charge.
More info: Navneet Kaur, Purvi Mathur, Pranjali Yadav, Swaroop Chakraborty, Asifkhan Shanavas, Glycol chitosan in situ coating on PLGA nanoparticle curtails extraneous paclitaxel precipitates and imparts protein corona independent hemocompatibility, Carbohydrate Polymers, 2020. 237, 116170.