Faculty Directory

Dr. Shyam Lal M

Scientist-C

Our research thrusts is to engineering delivery systems for poorly water soluble drugs towards therapeutic clinical applications primarily, against neglected infectious diseases (Visceral Leishmaniasis). We focus on the development of nanomedicines based on biological nanomaterials with considerable priority on interface between in vitro and in vivo studies and how logically-designed and engineered drug delivery systems can be translated into clinically-effective therapeutics.

CONTACT INFORMATION :

Research Interest

  • Developing targeting moieties for nanoparticle drug delivery towards visceral leishmaniasis.
    Biocompatible and Biodegradable nanoparticles for therapeutics: A Nano approach.
    Understanding the interactions of nanomaterials and biological system.

Research Highlights

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  1. Mannose-conjugated curcumin-chitosan nanoparticles: Efficacy and toxicity assessments against Leishmania donovani: Chaubey P, Mishra B, Patel RR, Chaurasia S, Sundar S, Suvarna V, Monteiro M, (2018) Int J Biol Macromol, 111: 109-120. DOI: 10.1016/j.ijbiomac.2017.12.143

  2. Medicherla V Jagannadham, Shyam Sundar, Biswajit Ray, Galactosylated Chitosan for Enhanced and Efficient Antimicrobial and Antileishmanial Activities: Niraj Kumar Vishwakarma, Vijay Kumar Patel, Ravi Kumar, Tanu Gupta, Kalyan Ramesh, Karun Jana, P. K. Dutta, Pralay Maiti, Nira Mishra, (2015) A Novel Approach, Asian Chitin J, 11 (2): 11-18.

  3. Characterization and evaluation of amine modified graphene Amphotericin B for the treatment of visceral leishmaniasis: in vivo and in vitro studies: Talat M, Rai M, Srivastava ON, Sundar S, (2014) Drug Design, Development and Therapy, 8: 1235-47. DOI: 10.2147/DDDT.S63994

  4. In vivo assessment of antileishmanial property of 4-(4, 4, 8-Trimethyl 7-oxo-3-oxabicyclo [3.3.1] non-2-yl)-benzoic acid methyl ester, an oxabicyclo [3.3.1] nonanones, in hamster model: Prakash Saudagar, Pipas Saha, Anil K. Saikia,Vikash Kumar Dubey,Shyam Sundar, (2014) Letters in Drug Design & Discovery, 11: 937-939. DOI: 10.2174/1570180811666140423203826

  5. Amine modified graphene mediated drug delivery of Amphotericin B for the treatment of visceral leishmaniasis: M. Rai, M. Talat, O.N. Srivastava, S. Sundar, (2014) International Journal of Infectious Diseases, 21S: 1–460. DOI: 10.1016/j.ijid.2014.03.753

  6. Comparative Evaluation of Blood and Serum Samples in Rapid Immunochromatographic Tests for Visceral Leishmaniasis: Kumar D, Khanal B, Tiwary P, Tiwary NK, Singh R, Koirala K, Boelaert M, Rijal S, Sundar S., (2013) J Clin Microbiol., 51(12): 3955-9.. DOI: 10.1128/JCM.01232-13

  1. Oxabicyclo derivatives as novel antileishmanial compound: Prakash Saudagar, Vikash Kumar Dubey, Anil Kumar Saikia, Pipas Saha,Shyam Sundar, (2013) .

  1. An oral formulation of Amphotericin B for the treatment of visceral Leishmaniasis: f-Gr-AmB: M Talat, M Rai, ON Srivastava, S Sundar, (2016) International Journal Of Infectious Diseases, 45: 3067. DOI: 10.1016/j.ijid.2016.02.790

  2. International Conference on Infectious Disease, ICID 2016: Hyderabad, (2016) .

  3. 6th MRS Trilateral Symposium: INST, Mohali, (2015) .

  4. International Conference on Translational Nanomedicine, T-NANO 2014: Ahmedabad, Gujarat, (2014) .

  5. 10th International Congress & Exhibition on Nanobiotechnology Diseases: Munster Germany, (2014) .

  6. The 2nd National Conference on Primary Immuno Deficiency Diseases (PIDCON 2014): IMS BHU Varanasi, (2014) .

  7. 6th International Conference on Nano Science and Technology (ICONSAT 2014): Punjab University, (2014) .

  8. International Conference on Chemical biology Disease Mechanisms and Therapeutics (ICCB 2014): Hyderabad, (2014) .

Fundings

  • Development of modified lipid nanovesicles based oral drug delivery system for the treatment of visceral leishmaniasis 2018-2021, SERB, DST
    Funding Amount: 4945968
    PI: Dr. Shyam Lal M

  • 2015

    Ph.D Biochemistry

    Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

  • 2009

    M.Sc Biochemistry

    Department of Biochemistry, School of Life Sciences, University of Hyderabad, Gachibowli, Andhra Pradesh, India

  • 2007

    B.Sc Biotechnology

    Osmania University, Hyderabad, Andhra Pradesh, India

  • Scientist C:Institute of Nano Science and Technology, Habitat Centre, Phase- 10, Sector- 64, Mohali - 160062, Punjab, India (January 2019 to Present till date )

  • Scientist B:Institute of Nano Science and Technology, Habitat Centre, Phase- 10, Sector- 64, Mohali - 160062, Punjab, India (February 2015 to December 2018 )

Awards & Honours

  • Awarded Early Career Research Award by SERB, DST, GOI.

  • Awarded Bill Melinda Gates-ICID Travel Grant for presenting work at ICID March 2-5, 2016, Hyderabad, India.

  • Awarded International Travel Award from ICMR for presenting work at International Congress & Exhibition on Nanobiotechnology organized by Centre of Nanotechnology from June 2- 4th 2014 in Munster, Germany.

  • Awarded Rajiv Gandhi National Fellowship 2011-12 by University Grants Commission, New Delhi, India for pursuing Ph.D.


Professional Recognitions